Insulin Resistance

Stress, infections and obesity

Stress or infections (urinary tract infections, pyoderma) can lead to a decline in the sensitivity of target tissues to insulin.

Other hormones

Endogenous or exogenous hormones may reduce the effects of insulin. When treating an animal for diabetes mellitus, medication with progestogens should be discontinued immediately. Intact bitches should be spayed. Read more

If animals are being treated with corticosteroids, alternatives to this treatment should be sought. If this is not feasible, efforts should be made to minimise the corticosteroid dose.

See the following two graphs for examples of blood glucose curves in a case of insulin resistance. Insulin was injected at time=0 hours.

Blood glucose curves

Blood Glucose Curve Insulin Resistance

Blood glucose measured in mmol/l
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Blood Glucose Curve Insulin Resistance

Blood glucose measured in mg/dl
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See blood glucose curves for details on making a glucose curve.

Insulin Resistance

Obese animals have reduced insulin sensitivity.