Aetiology of Diabetes Mellitus in Dogs

Canine diabetes mellitus can originate from:

• pancreatic disease
• non–pancreatic causes

Potential diabetes mellitus

Potential diabetes mellitus is defined as impaired insulin synthesis or secretion and/or decreased sensitivity of receptors to the effects of insulin. Hyperglycaemia is seen.

An increased blood glucose concentration that does not yet exceed the renal threshold can be seen in intact bitches during metoestrus. At this stage, the problem may still be reversible by spaying (removal of the progesterone source).

Hyperglycaemia may also be encountered in Cushing’s disease (hyperadrenocorticism); reversal of the cortisol excess may prevent the development of diabetes mellitus.