Feline diabetes due to Primary Pancreatic Disease

Diabetes mellitus is caused by inadequate synthesis or secretion of insulin.

Endocrine

The endocrine pancreas may not produce and secrete sufficient insulin.

feline diabetes - pancreas

Amyloidosis of islets of Langerhans in a cat, 25x
(Dept. of Pathology, Faculty of Veterinary Medicine, University of Utrecht.)

feline diabetes - pancreas

Amyloidosis of islets of Langerhans in a cat, congo red staining (right) and in polarized light (left), 25x
(Dept. of Pathology, Faculty of Veterinary Medicine, University of Utrecht.)

Exocrine

Severe inflammation (e.g. pancreatitis) or neoplasia of the exocrine pancreatic tissue can also lead to loss of islet function. In these cases diabetes is usually complicated by exocrine pancreatic insufficiency.

Feline diabetes due to Primary Pancreatic Disease

In cats amyloid deposition may contribute to the destruction of the islets.