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Fructosamine

Fructosamine and glycosylated haemoglobin (GHb) are two glycated proteins commonly used for monitoring diabetics.

These two proteins are markers of mean blood glucose concentration, with their concentration being proportional to the blood glucose concentration. The concentration of these proteins is not affected by stress; they are ideal for monitoring diabetic animals, particularily cats.

Fructosamine

The bonding of glucose to proteins produces fructosamines. A single fructosamine measurement indicates the average glucose concentration over the previous 2-3 weeks, based on the half-life of the plasma proteins.

The majority of diabetic animals will not always have optimal control of blood glucose thus fructosamine concentrations are unlikely to lie entirely within the reference range. Single fructosamine measurements should be interpreted in the light of clinical signs of diabetes, body weight and blood glucose concentration. In general, the closer the fructosamine concentration is to the reference range for healthy dogs and cats, the better the glycemic control.

Fructosamine reference ranges

(Reference: Feldman EC, Nelson RW (2004) Canine diabetes mellitus. In Canine and Feline Endocrinology and Reproduction. 3rd edition. Saunders, St Louis, USA p. 510)

(Reference: Feldman EC, Nelson RW (2004) Feline diabetes mellitus. In Canine and Feline Endocrinology and Reproduction. 3rd edition. Saunders, St Louis, USA p. 563)